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January 24, 2010 | History

Decorin-induced inhibition of collagen phagocytosis by fibroblasts 1 edition

Decorin-induced inhibition of collagen phagocytosis by fibroblasts
Vinay M. Bhide

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Decorin-induced inhibition of collagen phagocytosis by fibroblasts.

Published 2005 .
Written in English.

About the Book

Decorin (DCN) is a small, leucine-rich, extracellular matrix proteoglycan that binds collagen. We tested the hypothesis that DCN binding to collagen inhibits phagocytosis of collagen fibrils. Experimentally, this was achieved by analyzing the phagocytosis of collagen and DCN/collagen-coated fluorescent beads by Rat-2 and gingival fibroblasts. The binding and internalization of DCN/collagen-coated beads decreased dose-dependently with increasing concentrations of DCN (p<0.001). DCN-mediated inhibition of collagen phagocytosis was attributed to DCN-collagen interactions. A mimetic peptide corresponding to the leucine-rich repeat (LRR) 3 bound to a triple helical peptide containing the alpha2 integrin-binding site of collagen. When collagen beads were co-incubated with this peptide and a mimetic peptide for LRR 4, marked inhibition (∼55%) of collagen phagocytosis was observed. Thus, the DCN-mediated inhibition of collagen phagocytosis can be attributed to a novel collagen binding domain in DCN which acts co-operatively with LRR 4 to mask the alpha2beta1 integrin-binding site on collagen.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0740.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

Pagination
79 leaves.
Number of pages
79

ID Numbers

Open Library
OL19216657M
ISBN 10
0494072229

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page