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January 24, 2010 | History

The acylation of nucleosides, nucleotides and dinucleotides with biomimetically activated amino acids 1 edition

The acylation of nucleosides, nucleotides and dinucleotides with biomi ...
Amber Asad

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The acylation of nucleosides, nucleotides and dinucleotides with biomimetically activated amino acids.

Published 2005 .
Written in English.

About the Book

Lanthanide ions play a major role in selective monoacylation of diols in water by benzoyl methyl phosphate (BMP). Their role is via a mechanism of internal addition from the conjugate base of bis-bidentate complex of diol, BMP and lanthanum ion. We have shown that this mechanism of lanthanum catalysis is also applicable to nucleosides, nucleotides and dinucleotides for their selective monoacylation with aminoacyl ethyl phosphates. Derivatives of nucleosides and nucleotides lacking the diol moiety are unreactive. The monoacylation of 2'- or 3'-hydroxyl group of nucleosides and nucleotides, with no reaction at 5'-hydroxyl group or phosphate group, shows high selectivity. The role of lanthanum in the highly selective acylation of diols by aminoacyl phosphate in aqueous solutions can serve as biomimetic analogy to the enzymic acylation of tRNA with various aminoacyl adenylates.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0908.

Advisor: Ron Kluger

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

Pagination
49 leaves.
Number of pages
49

ID Numbers

Open Library
OL19216383M
ISBN 10
0494071486
OCLC/WorldCat
141837640

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page