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January 24, 2010 | History

Effect of mIL-10 immunomodulation on the viability of HEMA-MMA microencapsulated cells in vivo 1 edition

Effect of mIL-10 immunomodulation on the viability of HEMA-MMA microen ...
Marcin Surzyn

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Effect of mIL-10 immunomodulation on the viability of HEMA-MMA microencapsulated cells in vivo
assessment by a non-destructive method.

Published 2005 .
Written in English.

About the Book

Microencapsulation of cells in a polymer membrane has been proposed as a vehicle for the delivery of therapeutic biomolecules. Prior to encapsulation, CHO cells were engineered to express murine Interleukin-10 (mIL-10) and a firefly bioluminescence protein, luciferase, which allowed for non-invasive tracking of transplanted cells in vivo with the Xenogen IVIS Imaging System. Successful short-term modulation of the transplantation site microenvironment with mIL-10 secreted from within capsules was demonstrated at Days 10 and 21. At the rate produced by encapsulated cells, the murine Interleukin-10 did not cause long-term xenogeneic graft tolerance by the mouse host. As the cells within capsules began to die the reduced levels of secreted mIL-10 were likely insufficient to continue modulating the immune system, at least with cell viability as a marker. The accumulation of host cells around the implant likely contributed to the initial cell death due to nutrient or oxygen deficiency.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0961.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
121 leaves.
Number of pages
121

ID Numbers

Open Library
OL19216373M
ISBN 10
049407146X

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page