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January 24, 2010 | History

Single molecule force spectroscopy of membrane receptor-ligand interactions 1 edition

Single molecule force spectroscopy of membrane receptor-ligand interac ...
Haijun Ma

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Single molecule force spectroscopy of membrane receptor-ligand interactions
a model study.

Published 2005 .
Written in English.

About the Book

In principle, measuring the forces between individual molecules can provide novel insights into the specific interactions necessary to maintain or establish specific structure-function relationships. Recent advances in single molecule force spectroscopy using the scanning probe microscope have provided unique perspectives into the mechanics of protein unfolding and the dynamics of protein-protein interactions. Our work has focused primarily on membrane proteins and the nature of protein-membrane interactions. Using as our model system the well-studied cholera toxin and ganglioside receptor (GM1) complex, we have devised a strategy that allows us to measure the force required to extract the cholera toxin molecule from the GM1 molecules and the GM1 molecule from the membrane. Direct imaging confirmed extraction of a single cholera complex. Implications of this photoactivated coupling approach for the direct measurement of other single molecule interactions will be described.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0967.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
108 leaves.
Number of pages
108

ID Numbers

Open Library
OL19216331M
ISBN 10
0494071389

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page