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January 24, 2010 | History

Fast-gelling injectable drug delivery system for the injured spinal cord 1 edition

Fast-gelling injectable drug delivery system for the injured spinal co ...
Dimpy Gupta

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Fast-gelling injectable drug delivery system for the injured spinal cord.

Published 2005 .
Written in English.

About the Book

Neural protection strategies for spinal cord injury repair are limited due to poor drug delivery techniques. A drug delivery system is being developed in our laboratory that can provide localized and sustained release of growth factors from an injectable gel. The gel must be fast-gelling, non-cell adhesive, degradable, capable of sustainably releasing therapeutics, and biocompatible as an injectable intrathecal drug delivery system. A gel that meets these design criteria is a blend of hyaluronan and methylcellulose (HAMC). Unlike other injectable gels, HAMC is already at the gelation point prior to injection. It is injectable due to its shear-thinning property, and strengthens upon an increase in temperature. Release of erythropoietin is sustained over 3 days in vitro, and in vivo studies show that HAMC is biocompatible within the intrathecal space for 1 month. Hence, HAMC is a promising gel for the delivery of neural protective agents to the injured spinal cord.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0965.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
112 leaves.
Number of pages
112

ID Numbers

Open Library
OL19216289M
ISBN 10
0494071311

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page