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January 24, 2010 | History

Fast-gelling injectable drug delivery system for the injured spinal cord 1 edition

Fast-gelling injectable drug delivery system for the injured spinal co ...
Dimpy Gupta

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Fast-gelling injectable drug delivery system for the injured spinal cord.

Published 2005 .
Written in English.

About the Book

Neural protection strategies for spinal cord injury repair are limited due to poor drug delivery techniques. A drug delivery system is being developed in our laboratory that can provide localized and sustained release of growth factors from an injectable gel. The gel must be fast-gelling, non-cell adhesive, degradable, capable of sustainably releasing therapeutics, and biocompatible as an injectable intrathecal drug delivery system. A gel that meets these design criteria is a blend of hyaluronan and methylcellulose (HAMC). Unlike other injectable gels, HAMC is already at the gelation point prior to injection. It is injectable due to its shear-thinning property, and strengthens upon an increase in temperature. Release of erythropoietin is sustained over 3 days in vitro, and in vivo studies show that HAMC is biocompatible within the intrathecal space for 1 month. Hence, HAMC is a promising gel for the delivery of neural protective agents to the injured spinal cord.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0965.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

112 leaves.
Number of pages

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page