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January 24, 2010 | History

Incorporation of drug-eluting microspheres into biodegradable nerve guidance channels for controlled drug delivery 1 edition

Incorporation of drug-eluting microspheres into biodegradable nerve gu ...
Alex Goraltchouk

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Incorporation of drug-eluting microspheres into biodegradable nerve guidance channels for controlled drug delivery.

Published 2005 .
Written in English.

About the Book

Recent developments in molecular and systems biology have helped to identify a large volume of biomolecules capable of promoting nerve regeneration after spinal cord injury. As an alternative method of treatment, nerve guidance channels (NGCs) have been shown to promote nerve regeneration after transection of the spinal cord. Attempts of incorporating a drug delivery system (DDS) into the NGC have yielded sub-optimal designs due to low protein loading, uncontrolled release profiles and non-concentric geometries. We have developed a novel method of incorporating any microsphere based DDS into the NGC by physical entrapment in the annulus between two concentric tubes. Packing the NGCs with BSA-encapsulated microspheres resulted in the release of 260mug BSA over 84 days with a monotonic release rate. Release of EGF from a similar system showed that bioactive EGF was detected for over 14 days. This strategy should provide an effective method of localized delivery to the spinal cord.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0964.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
109 leaves.
Number of pages
109

ID Numbers

Open Library
OL19216279M
ISBN 10
049407129X

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page