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January 24, 2010 | History

Design and in vivo evaluation of the angiogenic potential of a poly(butyl methacrylate-co-methacrylic acid) tissue engineering scaffold 1 edition

Design and in vivo evaluation of the angiogenic potential of a poly(bu ...
Mark James Butler

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Design and in vivo evaluation of the angiogenic potential of a poly(butyl methacrylate-co-methacrylic acid) tissue engineering scaffold.

Published 2005 .
Written in English.

About the Book

Rapid vascularization of a tissue engineering scaffold upon implantation is key to its success in vivo as it promotes transplanted cell survival and host tissue integration. Previous work has demonstrated the pro-angiogenic potential of Methacrylic Acid containing copolymers in vivo. Poly(Butyl Methacrylate-co-Methacrylic Acid) (BMA-MAA) scaffolds were evaluated for their ability to promote angiogenesis in a subcutaneous implant model without the use of exogenous growth factors. Scaffolds fabricated by a novel in situ polymerization solvent casting/particulate leaching technique had high porosity (>80%) and pore size range 100-650mum. Compression testing of the scaffolds demonstrated a dependence on the compressive stiffness and yield strength for scaffold porosity, salt fusion time and choice of comonomer. Subcutaneous implantation of BMA-MAA scaffolds in mice revealed an increased level of histological angiogenesis in tissue invading the pores of the scaffold compared to a BMA control. These results support the hypothesis of BMA-MAA as an angiogenic biomaterial.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0956.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
107 leaves.
Number of pages
107

ID Numbers

Open Library
OL19216260M
ISBN 10
0494071257

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page