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January 24, 2010 | History

The use of gastric proton pump inhibitors to modulate osteoclast-mediated resorption of calcium phosphate cements 1 edition

The use of gastric proton pump inhibitors to modulate osteoclast-media ...
Aly R. Sheraly

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The use of gastric proton pump inhibitors to modulate osteoclast-mediated resorption of calcium phosphate cements.

Published 2005 .
Written in English.

About the Book

Recently, osteoclast-mediated resorption of calcium phosphate cement (CPC) was inhibited in vivo, by pre-loading them with a V-Type proton-ATPase pump inhibitor bafilomycin A1. An increase in peri-implant bone formation was also noted. However, bafilomycin is not clinically regulated and thus members of a class of regulated P-Type proton/potassium-ATPase inhibitors, specifically omeprazole and pantoprazole were examined. Increasing doses of these drugs were loaded into CPCs and implanted into femoral defects in rats. The response was examined histologically and by computer tomography for bone resorption and formation activity at the implant site. Pre-loading omeprazole and pantoprazole into CPCs inhibited osteoclast-mediated resorption of the implant, but no concurrent increase in peri-implant bone was observed at any of the doses tested. Overall, pre-loading this class of regulated drugs to inhibit resorption of CPC implants may provide a simple strategy to delay implant degradation in a clinical setting.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0961.

Thesis (M.A.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
108 leaves.
Number of pages
108

ID Numbers

Open Library
OL19216192M
ISBN 10
0494071125

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page