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January 24, 2010 | History

Quantitative and dynamic assessment of the contribution of the endoplasmic reticulum to phagosome formation 1 edition

Quantitative and dynamic assessment of the contribution of the endopla ...
Paul Paroutis

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Quantitative and dynamic assessment of the contribution of the endoplasmic reticulum to phagosome formation.

Published 2005 .
Written in English.

About the Book

Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An alternative model implicating the endoplasmic reticulum (ER) as a major component of nascent and maturing phagosomes was recently proposed (Gagnon, Duclos et al. 2002). To reconcile these disparate hypotheses, we used a combination of biochemical, fluorescence imaging and electron microscopy techniques to quantitatively and dynamically assess the contribution of the plasmalemma and ER during phagocytosis. We could not verify even a transient physical continuity between the ER and the plasma membrane, nor could we detect a significant contribution of the ER to forming or maturing phagosomes in either macrophages or dendritic cells. Instead, our data indicate that the plasma membrane is the main constituent of nascent and newly formed phagosomes, which are progressively remodeled by fusion with endosomal and lysosomal constituents as phagosomes mature into acidic, degradative organelles.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0907.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
135 leaves.
Number of pages
135

ID Numbers

Open Library
OL19216134M
ISBN 10
0494070986

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page