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January 24, 2010 | History

Morphological characterization of perinuclear GLUT4 distribution in L6 myoblasts 1 edition

Morphological characterization of perinuclear GLUT4 distribution in L6 ...
Chandrasagar B. Dugani

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Morphological characterization of perinuclear GLUT4 distribution in L6 myoblasts.

Published 2005 .
Written in English.

About the Book

Glucose transporter-4 (GLUT4) cycles to and from the plasma membrane and shows predominant perinuclear localization in unstimulated muscle and adipose tissues. This area is also occupied by recycling endosomes (RE), the Golgi complex, and the trans-Golgi network. Thorough characterization of insulin-responsive perinuclear compartments is lacking. Therefore, we evaluated insulin's effect on (i) the presence of GLUT4 in these compartments and (ii) the dynamics of perinuclear GLUT4 redistribution. We observed that insulin stimulation reduces the association of GLUT4 only with the RE and induces perinuclear GLUT4 remodelling that parallels the exocytic and internalization profiles of the transporter. Insulin-mediated GLUT4 translocation requires input from phosphatidylinositol-3-kinase (PI3-K), but the steps regulated are unknown. We show that mutants of (PI3-K), and its downstream molecule Akt Substrate 160 kDa (AS160) inhibit insulin-induced perinuclear GLUT4 remodelling. In summary, we characterize a novel insulin effect of perinuclear GLUT4 remodelling and demonstrate that it is regulated by the (PI3-K), → AS160 pathway.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0906.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

Pagination
91 leaves.
Number of pages
91

ID Numbers

Open Library
OL19216130M
ISBN 10
0494070978

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page