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January 24, 2010 | History

Effects of transient global ischemia on distribution and phosphorylation of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the synapse 1 edition

Effects of transient global ischemia on distribution and phosphorylati ...
Damanpreet Bawa

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Effects of transient global ischemia on distribution and phosphorylation of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the synapse.

Published 2005 .
Written in English.

About the Book

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are implicated in ischemia-induced neuronal death. We investigated the effects of global ischemia on distribution and phosphorylation of synaptic AMPARs in lipid rafts (DRMs), post-synaptic densities (PSDs) and extra-synaptic membranes (detergent soluble fraction) at various recovery times. We determined that 0.5% Triton X-100 (TX-100) with 1:1 detergent to protein ratio was the preferred condition to isolate post-synaptic DRMs. After ischemia, following an initial decrease there was a trend towards increase in synaptic AMPARs by 24 hours. AMPARs increased in PSDs at 6 hours in forebrain and hippocampus. GluR1 phosphorylation at Ser-831 decreased in DRMs and PSDs at 24 hours. Ser-845 showed increase in PSDs and transient changes in DRM and soluble fractions. Increased synaptic GluR1 is consistent with increased Ser-845 phosphorylation. The findings suggest that different synaptic populations of AMPARs are regulated differently after ischemia and lipid rafts may be involved in regulating AMPAR distribution.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0905.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (3 microfiches).

The Physical Object

Pagination
189 leaves.
Number of pages
189

ID Numbers

Open Library
OL19216125M
ISBN 10
049407096X

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page