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January 24, 2010 | History

The effects of recurrent restraint stress on counterregulation to subsequent stressors of restraint and hypoglycemia in diabetes 1 edition

The effects of recurrent restraint stress on counterregulation to subs ...
Jessica Tin Yan Yue

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The effects of recurrent restraint stress on counterregulation to subsequent stressors of restraint and hypoglycemia in diabetes.

Published 2006 .
Written in English.

About the Book

Our laboratory has shown impaired stress responsiveness, and defective hypoglycemic counterregulation following recurrent hypoglycemia, in diabetic rats. Presently, we investigate the effect of recurrent neurogenic stress on subsequent counterregulation to similar (homotypic, restraint) and different (heterotypic, hypoglycemia) stressors in non-diabetic and streptozotocin-diabetic rats. Naive control and recurrently restraint-stressed non-diabetic and diabetic rats were subjected to hypoglycemia and restraint, and counterregulatory hormones responses were measured. Diabetes resulted in impaired ACTH and corticosterone responses to restraint but enhanced ACTH, corticosterone, and epinephrine to responses hypoglycemia. Furthermore, diabetic rats showed hierarchy of hypoglycemic counterregulation. Rats showed similar glucagon habituation to homotypic stress, and epinephrine response in recurrently stressed diabetic rats was abolished. Moreover, heterotypic corticosterone and glucagon potentiation was lost in diabetic rats. These experiments show for the first time that recurrent neurogenic stress exerts divergent changes in diabetic stress counterregulation. These findings may have implications for daily stress management in diabetic patients.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2719.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
151 leaves.
Number of pages
151

ID Numbers

Open Library
OL19215954M
ISBN 13
9780494163917

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page