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April 28, 2010 | History

Purification and partial characterization of invertebrate visual arrestin from Loligo pealei 1 edition

Cover of: Purification and partial characterization of invertebrate visual arrestin from Loligo pealei by Walter L. Swardfager

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Purification and partial characterization of invertebrate visual arrestin from Loligo pealei.

Published 2006 .
Written in English.

About the Book

Light-dependent arrestin binding to rhodopsin was demonstrated in vitro. Membrane association was also stimulated by Ca2+ and inhibited by IP6. Ca2+-dependent interactions at the membrane apart from those with SQRK may contribute to Ca2+-dependent activation of arrestin as a SQRK substrate. Increases in arrestin phosphorylation were observed in the presence of conditions favoring membrane association, including Ca2+, light: and GTPgammaS.In Loligo pealei, activation of phototransduction involves conversion of rhodopsin to metarhodopsin, which activates Gq and the phospholipase C pathway. Inactivation involves rhodopsin phosphorylation and arrestin binding to metarhodopsin. Squid rhodopsin kinase (SQRK) can phosphorylate arrestin, in Ca2+-dependent manner, in addition to rhodopsin; a dual role unique among GRK proteins.This study reports the purification of squid visual arrestin. By dark-adaptation, light-sensitive rhabdomeric membranes were prepared, facilitating partial characterization of arrestin-membrane interaction. Light-prepared membranes lack light-sensitivity due to photobleaching and perhaps a lack of retinoid photoisomerase activity.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2778.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
117 leaves.
Number of pages
117

ID Numbers

Open Library
OL19215917M
ISBN 13
9780494163849

History Created December 11, 2009 · 3 revisions Download catalog record: RDF / JSON

April 28, 2010 Edited by Open Library Bot Linked existing covers to the work.
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page