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Characterization of biogenic amine receptors and their physiological roles in Caenorhabditis elegans 1 edition

Characterization of biogenic amine receptors and their physiological r ...
Rokhand Arvan

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Characterization of biogenic amine receptors and their physiological roles in Caenorhabditis elegans.

Published 2006 .
Written in English.

About the Book

We used C.elegans as a genetic model organism to provide a new insight of the mechanisms of biogenic amine signaling pathways in the context of the whole organism. Pharmacological and functional studies of DOP-1 receptor has previously confirmed its role as a D1-like dopamine receptor in vitro. We studied the physiological consequences of DOP-1 loss-of-function in the dop-1(ev748) mutant by analysis of various dopamine related behaviours in the worm. However, no defect in egg laying and locomotion behaviours were observed for the dop-1 mutant compared to the wild type animal. DOP-1 expression in mechanosensory neurons ALM, and PLM suggested a role in mechanosensory cues for this receptor. The response to tap, a diffused mechanical stimulus for testing mechanosensory control of locomotion, showed that dop-1 mutant animals habituate to repeated tap stimuli faster than wild type animals. The alteration in tap habituation phenotype was rescued by reintroducing a wild-type copy of the dop-1 gene into the dop-1(ev748) mutant under the control of its own promoter or the mechanosensory neuron mec-7 promoter. The human D1 receptor under the control of the mec-7 promoter also rescued the tap habituation phenotype in the dop-1(ev748) mutant. The data indicate that DOP-1 is involved in tap response behaviour in a cell autonomous manner. The observed defect in adaptive responses in dop-1(ev748) may provide an excellent model for understanding dopamine's role in modulating the behavioural plasticity in C.elegans and other organisms.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2774.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
167 leaves.
Number of pages
167

ID Numbers

Open Library
OL19215908M
ISBN 13
9780494163818

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page