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January 24, 2010 | History

Effect of immunosuppressants on endothelial progenitor cells 1 edition

Effect of immunosuppressants on endothelial progenitor cells
Santiago G. Miriuka

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Effect of immunosuppressants on endothelial progenitor cells.

Published 2006 .
Written in English.

About the Book

Immunosuppressants are necessary to prevent graft rejection after solid organ transplantation. However, they are also known to have significant side effects, including endothelial toxicity. Endothelial progenitor cells originate in the bone marrow and are recognized by their angiogenic and endothelial reparative properties. The effects of the immunosuppressants cyclosporine A (CyA), tacrolimus and rapamycin were analyzed on peripheral blood mononuclear cells under conditions which support growth of endothelial progenitor cells, as well as related cell types. The effect of rapamycin was profound upon endothelial progenitor cells. A much lesser effect was observed in mature human aortic endothelial cells, macrophages or late-outgrowth endothelial progentor-like cells. CyA and tacrolimus had no significant effects at clinical concentrations. The mechanism of cell death appeared to be apoptosis induced by a diverse mechanism. In conclusion, rapamycin induces endothelial progenitor cell death, probably related to the blockage of the necessary stimulatory drive on these cells given by growth factors.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2757.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

141 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page