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January 24, 2010 | History

Inter-individual variations in genome-wide DNA methylation patterns in the human germline 1 edition

Inter-individual variations in genome-wide DNA methylation patterns in ...
Martha Sobolev

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Inter-individual variations in genome-wide DNA methylation patterns in the human germline.

Published 2006 .
Written in English.

About the Book

Heritable epigenetic modification is an additional layer of information that is stored in the human genome, and contributes to inter-individual phenotypic heterogeneity. Epigenetic misregulation of critical processes such as imprinting, X-chromosome inactivation, and the transcriptional control of genes contributes fundamentally to the etiology of many human diseases. In this study I demonstrate the existence of differences in DNA methylation profiles in germ-cells between healthy males. The experimental strategy included the scanning of CpG islands with microarrays to identify regions of high and low inter-individual variability in DNA methylation patterns in the genome, which was then confirmed with detailed SNaPshot analysis. In addition, a number of genes exhibited age-related methylation changes. Further research may focus on the elucidation of the extent of epigenetic inheritance in humans, a process that may explain why some diseases appear to be sporadic, show weak genetic linkage, or are late-onset.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2777.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
87 leaves.
Number of pages
87

ID Numbers

Open Library
OL19215840M
ISBN 13
9780494163832

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page