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January 24, 2010 | History

Pharmacogenetic analysis of dopamine receptor gene polymorphisms and clinical response to clozapine in patients with schizophrenia 1 edition

Pharmacogenetic analysis of dopamine receptor gene polymorphisms and c ...
Rudi Hwang

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Pharmacogenetic analysis of dopamine receptor gene polymorphisms and clinical response to clozapine in patients with schizophrenia.

Published 2006 .
Written in English.

About the Book

Clozapine is the prototype atypical antipsychotic indicated primarily for schizophrenic patients either refractory or intolerant to typical antipsychotics. Even for this patient population however clinical response to clozapine is highly variable. The effects of all antipsychotics on the symptoms of schizophrenia, including clozapine, are thought to be mediated, at least in part, through their interactions with the dopaminergic system via various dopamine receptor subtypes. Furthermore, twin case-studies provide evidence that there is a genetic basis for the observed inter-patient variability in antipsychotic response. Therefore, genetic variants which affect the function and/or density of dopamine receptors may help to explain some of this observed variability. This thesis presents association studies of dopamine D1 and D2 receptor polymorphisms on clozapine response after 6 months treatment in Caucasian and African American schizophrenic patient populations. Both categorical (responder/non-responder) and quantitative measures (% change score) of treatment response were used.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2775.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
96 leaves.
Number of pages
96

ID Numbers

Open Library
OL19215837M
ISBN 13
9780494163740

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page