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January 24, 2010 | History

DNA palindrome metabolism 1 edition

DNA palindrome metabolism
Julia Hearn Appleby

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DNA palindrome metabolism.

Published 2006 .
Written in English.

About the Book

DNA palindromes consist of two perfectly inverted repeats, creating a central axis of symmetry. Palindromes can adopt cruciform structure and can promote gross genomic instability in mammals. In this thesis, I have investigated the biological outcome of palindromy in murine cells at a mechanistic level using two complementary assays. In the first, using the Line 78 mouse model, I have characterized a new system for monitoring quasipalindrome correction of a mismatched palindrome. I have shown that both quasipalindrome correction and palindrome rearrangement require cruciformation from dsDNA as an initiating event and have proposed a new model of quasipalindrome correction termed the Hairpin Conversion Model. In the second assay, performed by the transfection of an extrachromosomal palindrome, I have shown that palindrome rearrangement occurs independently of the 'canonical' NHEJ pathway in mammalian cells. Additionally, I have characterized the insertion of filler DNA as a feature of palindrome metabolism in both assays.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2706.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
127 leaves.
Number of pages
127

ID Numbers

Open Library
OL19215776M
ISBN 13
9780494163610

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page