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January 24, 2010 | History

DNA palindrome metabolism 1 edition

DNA palindrome metabolism
Julia Hearn Appleby

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DNA palindrome metabolism.

Published 2006 .
Written in English.

About the Book

DNA palindromes consist of two perfectly inverted repeats, creating a central axis of symmetry. Palindromes can adopt cruciform structure and can promote gross genomic instability in mammals. In this thesis, I have investigated the biological outcome of palindromy in murine cells at a mechanistic level using two complementary assays. In the first, using the Line 78 mouse model, I have characterized a new system for monitoring quasipalindrome correction of a mismatched palindrome. I have shown that both quasipalindrome correction and palindrome rearrangement require cruciformation from dsDNA as an initiating event and have proposed a new model of quasipalindrome correction termed the Hairpin Conversion Model. In the second assay, performed by the transfection of an extrachromosomal palindrome, I have shown that palindrome rearrangement occurs independently of the 'canonical' NHEJ pathway in mammalian cells. Additionally, I have characterized the insertion of filler DNA as a feature of palindrome metabolism in both assays.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2706.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

127 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page