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January 24, 2010 | History

Investigating smooth muscle cell marker gene expression in distinct regions of the mouse aorta during early atherosclerosis by microdissection and mRNA analysis 1 edition

Investigating smooth muscle cell marker gene expression in distinct re ...
Shivalika Handa

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Investigating smooth muscle cell marker gene expression in distinct regions of the mouse aorta during early atherosclerosis by microdissection and mRNA analysis.

Published 2006 .
Written in English.

About the Book

Smooth muscle cell (SMC) markers of differentiation are known to down-regulate in late stages of atherosclerosis, a process known as dedifferentiation. However, it is unknown whether, as with endothelial cells, any regional differences in SMC gene expression exist during early stages of atherosclerosis. From various methods of microdissection, optimal techniques were identified for harvesting SMC from distinct regions of the mouse aorta. Several internal control genes were tested for real time RT-PCR, and beta-2-microglobulin was most reliable. No detectable differences in SMC marker gene expression exist at baseline between three different regions of the mouse aorta. Surprisingly, temporal increases in SMC marker gene expression were observed in areas of high probability for subsequent lesion formation. These changes occurred in the presence of only limited inflammatory cell infiltration and lipid deposition. These observations may indicate that dedifferentiation of SMC during atherosclerosis is not an early event in disease progression.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2708.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
112 leaves.
Number of pages
112

ID Numbers

Open Library
OL19215766M
ISBN 13
9780494163597

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page