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January 24, 2010 | History

The effect of tobacco exposure on the fetal hypothalamic-pituitary-adrenal axis 1 edition

The effect of tobacco exposure on the fetal hypothalamic-pituitary-adr ...
Sarah D. McDonald

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The effect of tobacco exposure on the fetal hypothalamic-pituitary-adrenal axis.

Published 2006 .
Written in English.

About the Book

Background. In utero "programming" of the hypothalamic-pituitary-adrenal (HPA) axis may occur if cigarette smoking induces a state of chronic oxidative stress in the fetus. I sought to determine the relationship between in utero tobacco exposure and cortisol levels.Methods. This was a prospective cohort study of 21 term infants of smoking mothers and 83 infants of non-smoking mothers.Results. Baseline characteristics were similar although smokers were younger, with lower incomes and education levels. Infants of smokers weighed less and had significantly elevated ACTH levels compared with non-exposed infants (17 +/- 13 pmol/L versus 9 +/- 10 pmol/L, respectively, p=0.004). Cortisol levels were not significantly different. Multiple linear regression revealed that umbilical venous cortisol accounted for the largest amount of variance in umbilical arterial cortisol, R2=39.8%.Conclusions. Infants exposed to in utero tobacco smoke have significantly elevated ACTH levels compared with non-exposed infants, a potential set up for "programming" of the HPA axis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2753.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
76 leaves.
Number of pages
76

ID Numbers

Open Library
OL19215744M
ISBN 13
9780494163566

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page