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January 24, 2010 | History

The role of central and peripheral influences in the chronic hypercapnia-induced increase in central pH/carbon dioxide chemoreception 1 edition

The role of central and peripheral influences in the chronic hypercapn ...
Afshan Gheshmy-Bakht

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The role of central and peripheral influences in the chronic hypercapnia-induced increase in central pH/carbon dioxide chemoreception.

Published 2006 .
Written in English.

About the Book

This study examined, in cane toads (Bufo marinas), four possible mechanisms responsible for the increase in central pH/CO2-sensitive fictive breathing that occurs following chronic hypercapnia: (1) altered activity from midbrain centres; (2) increases in olfactory CO2 chemoreceptor input; (3) increases in carotid labyrinth chemoreceptor input; (4) increases in carbonic anhydrase activity. Toads were exposed to chronic hypercapnia (3.5% CO2) for 9 days and in vitro brainstem-spinal cord preparations were used to examine central pH/CO2-sensitive fictive breathing. Midbrain transection did not alter the effects of chronic hypercapnia described above, suggesting supramedullary influences were not involved. Olfactory denervation as well as simultaneous exposure to chronic hyperoxia/hypercapnia eliminated the effects of chronic hypercapnia on fictive breathing, suggesting that breathing changes following chronic hypercapnia may result from altered peripheral chemoreceptor input. Carbonic anhydrase inhibition with acetazolamide had different effects following chronic hypercapnia, suggesting a change in carbonic anhydrase activity with chronic hypercapnia.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2723.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
154 leaves.
Number of pages
154

ID Numbers

Open Library
OL19215486M
ISBN 13
9780494162354

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page