Open Library logo
New Feature: You can now embed Open Library books on your website!   Learn More
Last edited by WorkBot
January 24, 2010 | History

Myometrial differentiation during pregnancy 1 edition

Myometrial differentiation during pregnancy
Prudence Pui-Hing Tsui

Prefer the physical book? Check nearby libraries with:

Buy this book

There's no description for this book yet. Can you add one?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Myometrial differentiation during pregnancy.

Published 2006 .
Written in English.

About the Book

From a quiescent state in early pregnancy to a highly contractile state in labour, the myometrium displays tremendous growth and remodeling which is thought to occur as a result of phenotypic modulation of uterine smooth muscle cells (SMCs). This study tested the hypothesis that during pregnancy, phenotypic modulation of myometrial SMCs is regulated by endocrine and mechanical signals that are mediated by growth factors and cytokines, and the eventual onset of contractile phenotype is characterized by changes in contractile machinery. We demonstrated that the gene expression of growth factors (IGF system, TGFbeta family, EGFR), cytokines (Ccl2, HGF, Edn system), and contractile proteins (actins, alpha-Tpm, SM22alpha) were affected by pregnancy in the rat myometrium. They were differentially expressed associated with particular phase(s) of myometrial differentiation. Furthermore, TGFbeta3 protein expression was found to be stretch-regulated near term. Taken together, these results suggest that programmed differentiation of myometrial SMCs is regulated by growth factors, cytokines, and contractile proteins.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2719.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

158 leaves.
Number of pages

ID Numbers

Open Library


Download catalog record: RDF / JSON
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page