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January 24, 2010 | History

Controlling arterial gases during spontaneous ventilation: A new approach to in vivo studies of cerebrovascular reactivity 1 edition

Controlling arterial gases during spontaneous ventilation: A new appro ...
Marat V. Slessarev

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Controlling arterial gases during spontaneous ventilation: A new approach to in vivo studies of cerebrovascular reactivity.

Published 2006 .
Written in English.

About the Book

I used basic physiological principles to develop a simple feed-forward method of attaining and controlling target arterial PO2 and PCO 2 through the manipulation of alveolar gas concentrations in spontaneously breathing subjects. Contrary to common wisdom which, as stated in the Journal of Applied Physiology, states that "...the CO2 and O2 effects on the CBF are physiologically inseparable", my method is able to vary the partial pressure of each gas independently. I was therefore able to examine the effects of each gas separately on CBF. Using a transcranial Doppler to monitor cerebral blood flow I showed that cerebrovascular response to changes in alveolar PCO2 at sustained normoxia has a very short time constant which implies that it responds directly to arterial rather than brain tissue PCO2. Second, I showed that changes in arterial PO 2 confounds interpretation of common CO2-induced cerebrovascular reactivity measures when BOLD MRI signal is used to indicate cerebral blood flow.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2719.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
95 leaves.
Number of pages
95

ID Numbers

Open Library
OL19215347M
ISBN 13
9780494162088

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page