Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

The role of Helicobacter pylori cage in the apoptosis of macrophages 1 edition

The role of Helicobacter pylori cage in the apoptosis of macrophages
Amy Adel Sharaf

Read

No readable version available.

Lists

You could add The role of Helicobacter pylori cage in the apoptosis of macrophages to a list if you log in.
What the..? There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

The role of Helicobacter pylori cage in the apoptosis of macrophages.

Published 2006 .
Written in English.

About the Book

Helicobacter pylori is a gram-negative, bacterium that infects 50% of the world's human population. During infection, the host elicits a vigorous immune response that is insufficient to clear infection. H. pylori-mediated apoptosis of macrophages could be a possible mechanism of immune evasion. However, the bacterial factors which trigger apoptosis remain unclear. Therefore, we determined the role of cagE during H. pylori-mediated apoptosis of macrophages. Following infection with the cagE- mutant, an increase in macrophage apoptosis was detected, compared with cells infected with the wildtype (wt) H. pylori strain or uninfected controls. An increase in ERK1/2 MAPK phosphorylation was detected in cagE--infected macrophages. In addition, incubation of wt or cagE--infected macrophages with a pharmacological inhibitor, which prevents ERK1/2 phosphorylation, reduced apoptosis. These results indicate that cagE exerts anti-apoptotic effects during the infection of macrophages through the modulation of ERK1/2 MAPK.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2706.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
109 leaves.
Number of pages
109

ID Numbers

Open Library
OL19215339M
ISBN 13
9780494162071

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page