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January 24, 2010 | History

The effect of insulin on neointimal growth and matrix metalloproteinases in the rat model of balloon catheter injury of the carotid artery 1 edition

The effect of insulin on neointimal growth and matrix metalloproteinas ...
Jiwanjeet Kaur Dhaliwall

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The effect of insulin on neointimal growth and matrix metalloproteinases in the rat model of balloon catheter injury of the carotid artery.

Published 2006 .
Written in English.

About the Book

In vitro studies have shown insulin to have both atherogenic and anti-atherogenic effects whereas the effect of insulin in vivo is still unclear. In the first study I investigated the effect of normoglycemic hyperinsulinemia achieved via oral glucose administration and oral glucose administration alone on neointimal growth 14 days after arterial injury and demonstrated that insulin decreased neointimal growth independent of glucose-lowering or need for oral glucose administration. In the second study I assessed the effect of normoglycemic hyperinsulinemia on matrix metalloproteinases (MMPs) 4 days after arterial injury. MMPs are the main mediators of smooth muscle cell (SMC) migration after arterial injury. I demonstrated that insulin decreased pro-MMP-2 and MMP-2 gelatinolytic activity by decreasing the expression of MMP-2. Insulin also decreased MMP-9 gelatinolytic activity. These results suggest that insulin can reduce intimal growth by decreasing MMP activity. The results from both studies suggest that insulin has anti-atherogenic effects in vivo.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2718.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
126 leaves.
Number of pages
126

ID Numbers

Open Library
OL19215328M
ISBN 13
9780494162040

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page