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January 24, 2010 | History

Chemoreflex responsiveness and sleep apnea in end-stage renal disease 1 edition

Chemoreflex responsiveness and sleep apnea in end-stage renal disease
Jaime Beecroft

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Chemoreflex responsiveness and sleep apnea in end-stage renal disease.

Published 2006 .
Written in English.

About the Book

Sleep apnea (SA) occurs in up to 50% of patients with end-stage renal disease (ESRD) and is improved by nocturnal hemodialysis (NHD). This study tested the hypothesis that its pathogenesis is related to altered chemoreflex responsiveness (CRR). Patients receiving conventional hemodialysis (CHD) underwent overnight polysomnography and assessment of CRR using a re-breathing technique. Measurements were repeated 3-6 months following conversion from CHD to NHD. Patients were divided into apneic and non-apneic groups based on an apnea-hypopnea index (AHI) >15/hr on CHD and apneic patients were further divided into "responders" and "non-responders" based on >50% reduction in AHI with NHD. Conversion to NHD was associated with a significant decrease in CRR in apneic responders but not in non-responders and non-apneic patients. In conclusion, improvement of SA by NHD is associated with a decrease in CRR. This suggests that increased CRR contributes to the pathogenesis of SA in patients with ESRD.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2718.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

67 leaves.
Number of pages

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Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page