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January 24, 2010 | History

An assessment of the interaction of mitomycin C and doxorubicin in EMT6 mouse mammary tumor cells 1 edition

An assessment of the interaction of mitomycin C and doxorubicin in EMT ...
Adam Jason Shuhendler

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An assessment of the interaction of mitomycin C and doxorubicin in EMT6 mouse mammary tumor cells.

Published 2006 .
Written in English.

About the Book

Co-application of the chemotherapeutic agents mitomycin C and doxorubicin has been shown to result in supra-additive tumor cell killing in vitro and in vivo. The interaction of mitomycin C and doxorubicin was found to be a true synergy, as defined by the Median Effect Analysis (MEA). In vitro evidence identified mitomycin C-derived formaldehyde and glutathione levels in the cell as potential players. Reactive oxygen species were not detected from the metabolism of mitomycin C, contrary to previous reports, probably due to the 10-fold lower drug concentration used herein. Since DNA cross-links were found to only increase additively with co-administration of the drugs, we propose that the poisoning of topoisomerase IIalpha by doxorubicin interacts with the drug-induced DNA cross-links. Therefore, the synergy observed between mitomycin C and doxorubicin may be elicited through mitomycin C-derived formaldehyde, glutathione depletion and the enhanced genotoxicity of the combination of DNA cross-links and topoisomerase IIalpha poisoning.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2777.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
89 leaves.
Number of pages
89

ID Numbers

Open Library
OL19215293M
ISBN 13
9780494161975

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page