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January 24, 2010 | History

Non-invasive molecular imaging of an EGFP and DRD2-expressing vaccinia virus 1 edition

Non-invasive molecular imaging of an EGFP and DRD2-expressing vaccinia ...
Navneet Mehta

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Non-invasive molecular imaging of an EGFP and DRD2-expressing vaccinia virus.

Published 2006 .
Written in English.

About the Book

As oncolytic vectors for cancer therapy come to clinical trials, noninvasive monitoring of vector biodistribution will be necessary. Oncolytic vaccinia viruses (rVV) preferentially target, infect and replicate in tumours. The goal of this research was to develop non-invasive strategies of monitoring rVV in vivo. Upon subcutaneous murine colon cancer tumour formation and subsequent systemic administration of rVV in athymic mice, we acquired whole-body mouse images by nuclear medicine or optical (fluorescence) techniques. Fluorescence imaging revealed the earliest time-point of enhanced green fluorescent protein (EGFP) detection and persistence in tumours of mice infected with an EGFP-expressing rVV. In vitro binding studies confirmed specific radioligand binding of 111In-pentetreotide and [123I]IBF to vaccinia virus-mediated expression of human somatostatin receptor subtype 2 (hSSTR2) and the dopamine D2 receptor (DRD2) on tumour cells, respectively. In vivo studies examined biodistribution and specificity of 111In-Pentetreotide and [123I]IBF in athymic mice after systemic delivery of vvDD-hSSTR2 and vvDD-EGFP-DRD2, respectively. Optical and nuclear imaging of rVV expressing EGFP, hSSTR2, and DRD2 provides a non-invasive assessment of vector biodistribution and persistence, and potentially will be able to image tumour responses.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2776.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

124 leaves.
Number of pages

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Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page