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January 24, 2010 | History

Characterization of the transient receptor potential channels mediating lysophosphatidic acid-stimulated calcium mobilization in B lymphoblasts 1 edition

Characterization of the transient receptor potential channels mediatin ...
Angela S. Roedding

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Characterization of the transient receptor potential channels mediating lysophosphatidic acid-stimulated calcium mobilization in B lymphoblasts.

Published 2006 .
Written in English.

About the Book

Altered 1-oleoyl-lysophosphatidic acid (LPA, 100 muM)-stimulated calcium responses occur in B-lymphoblast cell lines from bipolar disorder patients, but the mechanism(s) involved is uncertain. LPA shares a structurally similar fatty acid side chain with the diacylglycerol analogue, 1-oleoyl-2-acetyl-sn-glycerol (OAG), a known activator of subtypes 3, 6 and 7 of the canonical transient receptor potential (TRPC) cation channel subfamily. Accordingly, the objective of this study was to determine whether the LPA-stimulated calcium response in B-lymphoblasts is mediated, in part, through this TRPC channel subfamily. Divalent cation selectivity in response to thapsigargin, LPA and OAG was used to distinguish TRPC-like character from store-operated channels. The results suggest that 100 muM LPA stimulates calcium entry through channels with characteristics similar to TRPC3/6/7. The findings of enhanced LPA-stimulated calcium responses from bipolar disorder compared with healthy subjects may implicate dysfunction of TRPC3-like calcium entry in the pathophysiology of bipolar disorder.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2777.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
109 leaves.
Number of pages
109

ID Numbers

Open Library
OL19215266M
ISBN 13
9780494161920

History

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page