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January 24, 2010 | History

An examination of synaptic proteins following chronic haloperidol treatment in a rat model of tardive dyskinesia 1 edition

An examination of synaptic proteins following chronic haloperidol trea ...
Mona Kessas

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An examination of synaptic proteins following chronic haloperidol treatment in a rat model of tardive dyskinesia.

Published 2006 .
Written in English.

About the Book

Tardive dyskinesia (TD) is a late-onset hyperkinetic side effect mainly affecting the orobuccal region of patients treated chronically with typical antipsychotics. In haloperidol-administered animals, we hypothesized that chronic haloperidol administration promotes faulty synaptic reorganization in a subpopulation causing a TD-like syndrome. We used the vacuous chewing movements (VCM) model of TD to investigate the expression of synaptophysin, syntaxin, spinophilm and PSD-95 in the striatum of treated animals. Male Sprague-Dawley rats were treated (12 weeks) with either haloperidol decanoate (I.M., 1mg/kg/day) or sesame oil then separated based on VCM behaviour. Using immunohistochernistry and Western Blot analysis, we found no significant effect of haloperidol (p>0.05) on protein levels. We also found no significant difference in the levels of the synaptic markers when comparing 'high' and 'low' VCM groups (p>0.05). These results suggest that synaptic alterations might not be the underlying mechanism of VCMs and possibly TD.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2775.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
106 leaves.
Number of pages
106

ID Numbers

Open Library
OL19215251M
ISBN 13
9780494161890

History

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page