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January 24, 2010 | History

Characterization of the novel mu opioid and D(1) dopamine receptor heterooligomer 1 edition

Characterization of the novel mu opioid and D(1) dopamine receptor het ...
Jason R. Juhasz

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Characterization of the novel mu opioid and D(1) dopamine receptor heterooligomer.

Published 2006 .
Written in English.

About the Book

Literature has suggested a possible association between the mu opioid and D1 dopamine receptors. Using BRET and a NLS-based assay, the mu opioid and D1 dopamine receptors were shown to specifically interact through the formation of a stable heterooligomer. Competition binding demonstrated no considerable changes in the binding affinities of either receptor following co-expression. However, single-point saturation binding displayed a significant increase in cell surface expression of the muOR upon co-expression with D1R, indicating novel regulation of receptor trafficking. Additionally, binding indicated a reduction in cell surface expression of the muOR upon co-expression with D5R, suggesting that these receptors may also heterooligomerize. A chimeric receptor approach was also utilized and suggests that select regions of the D1R are required for promoting muOR cell surface expression. Furthermore, immunocytochemistry demonstrated that these receptors co-localize in neurons of rat brain, supporting the possibility that these receptors may come into direct contact in vivo.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2775.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
109 leaves.
Number of pages
109

ID Numbers

Open Library
OL19215247M
ISBN 13
9780494161883

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page