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January 24, 2010 | History

Glyburide transport in the human mammary gland and the placenta 1 edition

Glyburide transport in the human mammary gland and the placenta
Jennifer Marie Kraemer

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Glyburide transport in the human mammary gland and the placenta
implications for developmental toxicology.

Published 2005 .
Written in English.

About the Book

Results. There was no detectable glyburide in any breast milk samples. There was significant transfer of glyburide against the concentration gradient from fetus to mother. Verapamil did not modify glyburide transport.Background. Oral hypoglycemics have been avoided due to assumptions that their placental transfer or transfer into breast milk may cause fetal-neonatal hypoglycemia. Glyburide transfer into breast milk has not been examined. Methods. Women were given a single oral dose of glyburide. Glyburide concentrations were determined in plasma and breast milk. In vitro perfusion studies of human cotyledon were performed to quantify placental transfer. In parallel experiments, verapamil (PgP inhibitor) was added.Conclusions. Glyburide in breast milk is not detectable above the LOD. The maximum relative infant exposure is negligible. This is the first direct evidence of active glyburide transport from the fetus to the mother. These experiments suggest that glyburide is actively effluxed by a transporter other than PgP.

Edition Notes

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 44-01, page: 0325.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches)

The Physical Object

Pagination
135 leaves.
Number of pages
135

ID Numbers

Open Library
OL20238588M
ISBN 10
0494022736

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page