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January 24, 2010 | History

Mechanisms of D(4) dopamine receptor-mediated platelet-derived growth factor receptor-beta transactivation 1 edition

Mechanisms of D(4) dopamine receptor-mediated platelet-derived growth ...
Marilyn S. Hsiung

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Mechanisms of D(4) dopamine receptor-mediated platelet-derived growth factor receptor-beta transactivation.

Published 2006 .
Written in English.

About the Book

The D4 dopamine receptor (DRD4) activates ERK1/2 and Akt via the transactivation of platelet-derived growth factor receptor-beta (PDGFRbeta). However, the mechanism by which this process occurs is not understood. In this thesis, site-specific PDGFRbeta phosphorylation was examined, and molecular and pharmacological methods were employed to investigate the role of various candidate mediators in this pathway. DRD4 stimulation results in the phosphorylation of the PDGFRbeta at the PI3K and PLCgamma binding sites. Pharmacological analysis reveals that DRD4-mediated Akt phosphorylation requires PI3K. Experiments involving the overexpression of beta-arrestin mutants, kinase-inactive c-src and csk, which negatively modulates src activity, indicate that these proteins do not participate in this transactivation cascade. Pharmacological studies suggest that calmodulin and PKCdelta act both upstream and downstream of the PDGFRbeta in DRD4-stimulated ERK1/2 phosphorylation. Although this present study supports a role for these proteins in DRD4-PDGFRbeta transactivation, further experiments are required to determine how these proteins are activated.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2775.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

113 leaves.
Number of pages

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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page