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January 24, 2010 | History

Diabetes susceptibility in drug-free schizophrenia patients and metabolic changes after second generation antipsychotic treatment 1 edition

Diabetes susceptibility in drug-free schizophrenia patients and metabo ...
Tony A. Cohn

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Diabetes susceptibility in drug-free schizophrenia patients and metabolic changes after second generation antipsychotic treatment.

Published 2006 .
Written in English.

About the Book

Patients treated with second generation antipsychotic medication over 12 weeks (n=7) had significant increases in bodyweight, fat weight, triglycerides, leptin and hs-CRP.Patients with schizophrenia have an increased prevalence of type-2 diabetes and accelerated coronary heart disease mortality. To investigate the metabolic consequences of the illness (schizophrenia) and treatment with second generation antipsychotic medication, the relevant literature was reviewed and two complimentary experiments were conducted.Unmedicated schizophrenia patients (n=9) had reduced insulin sensitivity (42%) and a tendency toward reduced adiponectin levels (30%), relative to matched healthy volunteers (n=9).These patients represent a newly defined "at risk" population from a metabolic and cardiac perspective and should be carefully monitored and managed for these risks.As a group, patients with schizophrenia have an increased susceptibility to type-2 diabetes and treatment with atypical antipsychotic medication results in adverse metabolic changes consistent with increased coronary heart disease risk.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2767.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
103 leaves.
Number of pages
103

ID Numbers

Open Library
OL19215216M
ISBN 13
9780494161821

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page