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January 24, 2010 | History

Keeping sisters together: Cohesin and Ycs4 define distinct mechanisms for sister chromatid cohesion 1 edition

Keeping sisters together: Cohesin and Ycs4 define distinct mechanisms ...
Wendy W. S. Lam

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Keeping sisters together: Cohesin and Ycs4 define distinct mechanisms for sister chromatid cohesion.

Published 2005 .
Written in English.

About the Book

The maintenance of genetic integrity during the eukaryotic cell cycle requires sister chromatid cohesion and chromosome condensation. I show that Ycs4p, a subunit of the condensin complex, has an important role in sister chromatid cohesion. My data suggest that Ycs4p functions in a distinct sister chromatid cohesion pathway from that mediated by the cohesin subunit Mcd1p. First, the two proteins localize independently on chromatin. Strikingly, and in contrast to cohesin mutants, a loss of Ycs4p-mediated cohesion can be efficiently re-established within mitosis following reactivation of the protein. Finally, Ycs4p appears specifically required for chromosomal arm cohesion but not at centromeric nor telomeric loci, whereas cohesins are needed throughout the chromosome length. Together these data demonstrate that Ycs4p is involved in a previously uncharacterized cohesin-independent mechanism for chromosome pairing in the budding yeast. This cohesion mechanism provides a unique opportunity to gain mechanistic insight into cohesin function and supports synapsis-based models for cohesin-dependent sister chromatid pairing.

Edition Notes

Source: Masters Abstracts International, Volume: 44-01, page: 0253.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

93 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page