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Last edited by WorkBot
January 24, 2010 | History

The septohippocampal cholinergic system in aging 1 edition

The septohippocampal cholinergic system in aging
Athena Rebecca Ypsilanti

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The septohippocampal cholinergic system in aging.

Published 2006 .
Written in English.

About the Book

The aging process has long been associated with a decrease in neuronal cell numbers in several brain areas. Recent applications of stereology have challenged this hypothesis by suggesting that the aging process is characterised by neuronal dysfunction, and perhaps axonal degeneration, rather than neuronal death. In this thesis, stereology was used to establish the status of cholinergic septohippocampal neuron number, size and fibre length in aged compared to young rats. We found that the number and the cross-sectional area of choline acetyltransferase (ChAT)-positive cell bodies remained constant in aging. However, the length of hippocampal ChAT-positive fibres was significantly reduced in aging (32% decrease). No changes in the activity of ChAT and the levels of nerve growth factor and brain-derived neurotrophic factor were detected in the hippocampus or medial septum. In conclusion, new stereological probes developed to measure fibre length densities represent a sensitive and powerful tool to evaluate axonal degeneration.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2774.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

96 leaves.
Number of pages

ID Numbers

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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page