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Last edited by WorkBot
January 24, 2010 | History

Characterizing anti-tumor activity mediated by double negative T cells 1 edition

Characterizing anti-tumor activity mediated by double negative T cells
Joyce Man-Yin Pun

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Characterizing anti-tumor activity mediated by double negative T cells.

Published 2006 .
Written in English.

About the Book

Recently our lab has demonstrated that infusion of allogeneic alphabetaTCR +CD3+CD4-CD8-NK1.1 - double negative (DN) T cell clones can eliminate tumor cells without causing graft versus host disease. Here we investigated whether primary DN T cells can prevent tumor progression and the mechanisms involved. We demonstrated that injection of single MHC-mismatched primary DN T cells can prevent tumor (A20) progression. Although DN T cells produced high amounts of IFNgamma, their cytotoxicity to A20 tumor is IFNgamma independent and contact dependent in vitro. Blocking the interactions between the T cell receptors (TCR) on DN T cells and alloantigen on tumors impaired their cytotoxicity, whereas transducing a single MHC class I alloantigen on syngeneic tumor cells is sufficient for DN T cells to recognize and kill tumor cells. These findings enhance our understanding of the anti-tumor activity of DN T cells, and suggesting DN T cells as a potential candidate for cancer immunotherapy.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2757.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

100 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page