Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

Effect of Treponema denticola major outer sheath protein on neutrophil functions in vitro 1 edition

Effect of Treponema denticola major outer sheath protein on neutrophil ...
Bina Agnes Puthengady Thomas

Read

No readable version available.

Lists

You could add Effect of Treponema denticola major outer sheath protein on neutrophil functions in vitro to a list if you log in.
Alas... There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Effect of Treponema denticola major outer sheath protein on neutrophil functions in vitro.

Published 2006 .
Written in English.

About the Book

The major outer sheath protein (Msp), a virulence determinant of the periodontal pathogen Treponema denticola, is known to perturb calcium and cytoskeletal dynamics that impacts cellular migration of fibroblasts. The aim of this study was to investigate the effects of enriched native Msp on key antimicrobial functions of human neutrophils (PMNs), namely chemotaxis, phagocytosis, and oxidative responses to agonists. Pretreatment of PMNs with Msp led to inhibition of chemotaxis and phagocytosis. Additionally, pretreatment of PMNs with Msp diminished fMLP-stimulated (i) amplitude of cytosolic Ca2+ transients, and (ii) the number of actin filament free barbed ends. However, Msp had no effect on PMN oxidative responses to fMLP or to phorbol myristate acetate, measured by the oxidation of dihydrorhodamine 123 by flow cytometry, and it did not induce apoptosis or plasma membrane permeability. T. denticola Msp selectively impairs human neutrophil locomotion, chemotaxis and phagocytosis in vitro through its impact on the cytoskeleton.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2751.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
74 leaves.
Number of pages
74

ID Numbers

Open Library
OL19214868M
ISBN 13
9780494161135

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page