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January 24, 2010 | History

Elastin-like polypeptide coated coronary artery stents 1 edition

Elastin-like polypeptide coated coronary artery stents
Colleen May McCracken

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Elastin-like polypeptide coated coronary artery stents.

Published 2006 .
Written in English.

About the Book

While stent implantation is one of the most effective methods of treating coronary artery disease, restenosis typically occurs at rates of 15-20% and is due primarily to thrombus formation and neointimal hyperplasia. Elastin, an insoluble cross-linked extracellular matrix protein, as well as small recombinant elastin-like polypeptides (ELPs), have been shown to inhibit platelet activation and degranulation, and to limit platelet adhesion. In this work, a method of coating stainless steel coronary artery stents with ELPs was developed by utilizing their ability to be cross-linked and coacervated. The in vitro platelet response to these coated stents was evaluated in both whole blood and platelet-rich plasma. While ELP coatings appeared to slightly lower both platelet-derived microparticle generation and P-selectin expression, no statistical significance could be attached to these effects. While platelet and cell adhesion to uncoated stent section was minimal, this adhesion was prevented in the presence of a cross-linked ELP stent coating.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2884.

Thesis (M.A.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
108 leaves.
Number of pages
108

ID Numbers

Open Library
OL19214668M
ISBN 13
9780494160787

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page