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January 24, 2010 | History

Regenerating spinal disc tissue using a vinyl-lysine urethane scaffold 1 edition

Regenerating spinal disc tissue using a vinyl-lysine urethane scaffold
Ankur Dudani

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Regenerating spinal disc tissue using a vinyl-lysine urethane scaffold.

Published 2006 .
Written in English.

About the Book

The focus of this work was to fabricate a biodegradable urethane-based scaffold and assess its suitability for annulus fibrosus (AF) regeneration. A vinyl-lysine urethane (VLU) scaffold (pore sizes between 30 and 250 mum; porosity = 70.0+/-5.0%) was synthesized by reacting a lysine-based polycarbonate divinyl oligomer with acrylate monomers in the presence of sodium bicarbonate salt crystals. A millipore filter cytotoxicity test, in conjunction with high performance liquid chromatography, was used to assess aspects of biocompatibility and indicated that the salt extraction process removed toxic unreacted acrylate monomers that were entrapped within the polymer matrix. In vitro biodegradation studies using cholesterol esterase to model in vivo macrophage hydrolytic activity showed that VLU scaffolds degraded 15.43+/-0.34% over a 4-week period. Bovine AF cells, maintained in three-dimensional culture, attached to VLU scaffolds and formed tissue containing glycosaminoglycans and collagen. These findings demonstrate the potential of using synthetic urethane-based scaffolds for AF regeneration.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2874.

Thesis (M.A.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

174 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page