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January 24, 2010 | History

Longitudinal characterization of the mesenchymal progenitor cell phenotype of Sca-1/Ly6A null mice 1 edition

Longitudinal characterization of the mesenchymal progenitor cell pheno ...
Christina Holmes

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Longitudinal characterization of the mesenchymal progenitor cell phenotype of Sca-1/Ly6A null mice.

Published 2006 .
Written in English.

About the Book

Stem cell antigen-1 (Sca-1/Ly6A) is a GPI-AP expressed by a variety of stem cell populations. Previous studies involving Sca-1 knockout (KO) mice revealed an age-related osteoporotic phenotype, characterized by decreased bone mass and bone brittleness, due to mesenchymal progenitor defects. In this study, the in vitro mesenchymal progenitor cell phenotype of Sca-1-/- mice and wild type BALB/ c controls was characterized at 3, 5, 7, 9 and 12 months of age. A significant defect in osteo-, adipo- and total mesenchymal progenitors in Sca-1-/- mice was found to arise between 5 and 7 months of age, as measured by the CFU-A, CFU-ALP/O, and CFU-F assays, persisting until at least 12 months. These defects encompass progenitor self-renewal, expansion, and potentially osteogenic and adipogenic differentiation. These results provide the baseline parameters enabling the use of Sca-1-/- mice in future studies as model of age-related osteoporosis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2875.

Thesis (M.A.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
174 leaves.
Number of pages
174

ID Numbers

Open Library
OL19214618M
ISBN 13
9780494160671

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page