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January 24, 2010 | History

Longitudinal characterization of the mesenchymal progenitor cell phenotype of Sca-1/Ly6A null mice 1 edition

Longitudinal characterization of the mesenchymal progenitor cell pheno ...
Christina Holmes

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Longitudinal characterization of the mesenchymal progenitor cell phenotype of Sca-1/Ly6A null mice.

Published 2006 .
Written in English.

About the Book

Stem cell antigen-1 (Sca-1/Ly6A) is a GPI-AP expressed by a variety of stem cell populations. Previous studies involving Sca-1 knockout (KO) mice revealed an age-related osteoporotic phenotype, characterized by decreased bone mass and bone brittleness, due to mesenchymal progenitor defects. In this study, the in vitro mesenchymal progenitor cell phenotype of Sca-1-/- mice and wild type BALB/ c controls was characterized at 3, 5, 7, 9 and 12 months of age. A significant defect in osteo-, adipo- and total mesenchymal progenitors in Sca-1-/- mice was found to arise between 5 and 7 months of age, as measured by the CFU-A, CFU-ALP/O, and CFU-F assays, persisting until at least 12 months. These defects encompass progenitor self-renewal, expansion, and potentially osteogenic and adipogenic differentiation. These results provide the baseline parameters enabling the use of Sca-1-/- mice in future studies as model of age-related osteoporosis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2875.

Thesis (M.A.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

174 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page