Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

Translocation of neisserial alpha-proteins into mammalian cells 1 edition

Translocation of neisserial alpha-proteins into mammalian cells
Wing Ming Lau

Read

No readable version available.

Lists

You could add Translocation of neisserial alpha-proteins into mammalian cells to a list if you log in.
Heavens to Betsy! There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Translocation of neisserial alpha-proteins into mammalian cells.

Published 2006 .
Written in English.

About the Book

Neisserial alpha-proteins are the domains of immunoglobulin A protease precursor that are co-secreted with IgA protease into the extracellular space. The alpha-proteins of Neisseria gonorrhoeae strain MS 11 (Ng) and Neisseria meningitidis strain Z2491 (Nm) were used for the investigation addressing these questions and the results are reported here. Cellular uptake assays indicated that a fusion protein consisting of Nm and the fluorescent protein Venus (VNm) had a higher efficiency of translocation and nuclear localization in HeLa cells than Venus tagged Ng (VNg). The mechanism of transduction for Nm alpha-proteins is temperature- and energy-independent; however, nuclear localization for VNm is both temperature- and energy-dependent and requires the binding of the nuclear transport adaptor karyopherin-alpha. As alpha-proteins are conserved during evolution and have characteristic properties, it is conceivable that they play a specific role in the survival mechanisms employed by Neisseria pathogens in the host cells.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2802.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

Pagination
104 leaves.
Number of pages
104

ID Numbers

Open Library
OL19214605M
ISBN 13
9780494160633

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page