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Translocation of neisserial alpha-proteins into mammalian cells 1 edition

Translocation of neisserial alpha-proteins into mammalian cells
Wing Ming Lau


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Translocation of neisserial alpha-proteins into mammalian cells.

Published 2006 .
Written in English.

About the Book

Neisserial alpha-proteins are the domains of immunoglobulin A protease precursor that are co-secreted with IgA protease into the extracellular space. The alpha-proteins of Neisseria gonorrhoeae strain MS 11 (Ng) and Neisseria meningitidis strain Z2491 (Nm) were used for the investigation addressing these questions and the results are reported here. Cellular uptake assays indicated that a fusion protein consisting of Nm and the fluorescent protein Venus (VNm) had a higher efficiency of translocation and nuclear localization in HeLa cells than Venus tagged Ng (VNg). The mechanism of transduction for Nm alpha-proteins is temperature- and energy-independent; however, nuclear localization for VNm is both temperature- and energy-dependent and requires the binding of the nuclear transport adaptor karyopherin-alpha. As alpha-proteins are conserved during evolution and have characteristic properties, it is conceivable that they play a specific role in the survival mechanisms employed by Neisseria pathogens in the host cells.

Edition Notes

Source: Masters Abstracts International, Volume: 44-06, page: 2802.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.

The Physical Object

104 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page