Beginning with Diego, a deaf-mute Mexican-American barely surviving on the border in El Paso, Texas, and progressing to the posh suburbs of San Francisco (where Diego's real sister, "Helen," has long ago abandoned him and her Chicano roots), Carry Me Like Water is an epic and immensely moving story that bluntly confronts divisions of race, gender, and class, fusing cultures and personal stories of people born in different Americas.

Helen and Eddie Marsh are living the pampered life of a yuppie couple expecting their first child - except that they've made a pact never to reveal anything about their childhood backgrounds.

Everything seems to move along fine in their idyllic rendition of the world until Helen's best friend, Lizzie, a dedicated AIDS nurse, begins to discover her own buried past after an unknown patient (who may or may not be her brother) blesses her on his deathbed with his remarkable telekinetic "gift" for out-of-body travel.

Lizzie's newfound power, in addition to her blossoming friendship with Jake and Joaquin - a young gay couple coping with AIDS - serves as a catalyst, bringing to light long-buried secrets and causing the disparate worlds of pain and privilege to collide.