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Last edited by Alice Kirk
March 8, 2016 | History
Fluid bed granulation in the form of agglomeration and coating processes are important unit operations used for many purposes in the biochemical and pharmaceutical industries. Although being simple in the fundamental principles, such processes are difficult to control and fully understand
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Publish Date
2013
Publisher
Bookboon
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Table of Contents
Introduction to fluid bed processing
Types of fluid beds
Important fluid bed parameters
The Geldart classification of particles
Advantages and disadvantages of fluid bed operations
The process and principles of Wet agglomeration
Introduction to the stages of the granulation processes
Wetting and nucleation
Granule growth behavior
Breakage and attrition
Simulation of the aggl. – a brief review on population balance theory
Summing up on wet aggl. – Qual. guidelines for param. influencing aggl.
Granule coating principles and properties in fluid beds
Parameters describing the coating process and result
Product, system and operating param. Aff. the coating process and effic.
Influence of product and formulation vari. on coated granule morphology
Aggl. or Coating?? – Qual. trends and attempts of find. a boundary param.
Qualitative description of key parameters governing the coating process
Mech. prop. of gran. and coating layer – strength and breakage mech.
Properties characterising the granule strength
Types of breakage mechanisms
Towards a quantitative prediction of breakage mechanisms
Qualitative trends of parameters affecting breakage
Modern approach – a brief rev. on computer sim. of granule breakage
Strength test methods – a brief review
Summing up on granule strength
Summary
Table of symbols
Literature
Appendix A1: Derivation of the equation 2.5
Appendix A2: From equation 2.5 to equation 2.7
Appendix A3: Derivation of the dimensionless spray flux
Appendix A4: Deriv. of Stokes viscous no. and Stokes critical viscous no.
Appendix A5: Derivation of equation 3.1 describing the coating thickness
Appendix A6: Derivation of equation 3.4
Notes
ID Numbers
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March 8, 2016 | Edited by Alice Kirk | Edited without comment. |
March 8, 2016 | Edited by Alice Kirk | Added new cover |
March 8, 2016 | Created by Alice Kirk | Added new book. |