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Last edited by Alice Kirk
June 5, 2015 | History
Fluid bed granulation in the form of agglomeration and coating processes are important unit operations used for many purposes in the biochemical and pharmaceutical industries. Although being simple in the fundamental principles, such processes are difficult to control and fully understand. In this text the processes and principles of fluid bed wet granulation processes are introduced together with an introduction to the mechanical properties of processed granules.
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Publish Date
2013
Publisher
Bookboon.com
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Book Details
Table of Contents
Content
1. Introduction to fluid bed processing
1.1. Types of fluid beds
1.2. Important fluid bed parameters
1.3. The Geldart classification of particles
1.4. Advantages and disadvantages of fluid bed operations
2. The process and principles of Wet agglomeration
2.1. Introduction to the stages of the granulation processes
2.2. Wetting and nucleation
2.3. Granule growth behavior
2.4. Breakage and attrition
2.5. Simulation of the aggl. – a brief review on population balance theory
2.6. Summing up on wet aggl. – Qual. guidelines for param. influencing aggl.
3. Granule coating principles and properties in fluid beds
3.1. Parameters describing the coating process and result
3.2. Product, system and operating param. Aff. the coating process and effic.
3.3. Influence of product and formulation vari. on coated granule morphology
3.4. Aggl. or Coating?? – Qual. trends and attempts of find. a boundary param.
3.5. Qualitative description of key parameters governing the coating process
4. Mech. prop. of gran. and coating layer – strength and breakage mech.
4.1. Properties characterising the granule strength
4.2. Types of breakage mechanisms
4.3. Towards a quantitative prediction of breakage mechanisms
4.4. Qualitative trends of parameters affecting breakage
4.5. Modern approach – a brief rev. on computer sim. of granule breakage
4.6. Strength test methods – a brief review
4.7. Summing up on granule strength
5. Summary
6. Table of symbols
7. Literature
8. Appendix A1: Derivation of the equation 2.5
9. Appendix A2: From equation 2.5 to equation 2.7
10. Appendix A3: Derivation of the dimensionless spray flux
11. Appendix A4: Deriv. of Stokes viscous no. and Stokes critical viscous no.
12. Appendix A5: Derivation of equation 3.1 describing the coating thickness
13. Appendix A6: Derivation of equation 3.4
14. Notes
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June 5, 2015 | Edited by Alice Kirk | Edited without comment. |
June 5, 2015 | Edited by Alice Kirk | Added new cover |
June 5, 2015 | Created by Alice Kirk | Added new book. |