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Physiological parameters for rhesus monkey and beagle dog (collected from literature) were tested in inhalation experiments with Forane. (Since Forane does not undergo biotransformation, its uptake and distribution depend solely on physiologocal parameters and solubility). Forane and methylene chloride were used to demonstrate species differences in vapor solubility in tissues of man, rhesus monkeys, beagle dogs, and Wistar rats. The experiments were performed to determine the metabolic coefficients of methylene chloride in monkey and dog. Published data was used to determine the coefficients of methylene chloride in man. These coefficients were used to model chronic exposures.
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Subjects
Perfusion, Chemical properties, Metabolism, Numerical Mathematics, Solubility, Dogs, Blood gases, Mathematics textbooks, Exposure(Physiology), Physiology, Partial pressure, Exponential functions, Gas chromatography, Inhalation, Textbooks, Mathematical models, Compartments, Excretion, Toxicology, Distribution, Toxicity, Methylenes, Humans, Vapors, Rhesus monkeys, Blood analysis, Pharmacokinetics, Concentration(Chemistry)Showing 1 featured edition. View all 1 editions?
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Biological - Mathematical Modeling of Chronic Toxicity
1975, Defense Technical Information Center
in English
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Ft. Belvoir
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APPROVED FOR PUBLIC RELEASE
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- Created July 16, 2011
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July 22, 2019 | Edited by MARC Bot | remove fake subjects |
August 11, 2011 | Edited by ImportBot | add ia_box_id to scanned books |
July 27, 2011 | Edited by ImportBot | import new book |
July 16, 2011 | Created by ImportBot | Imported from Internet Archive item record. |