The role of phosphatidylinositol-3 kinase isomers in myocardial ischemic preconditioning.

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The role of phosphatidylinositol-3 kinase iso ...
Kiwon Ban
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December 15, 2009 | History

The role of phosphatidylinositol-3 kinase isomers in myocardial ischemic preconditioning.

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Ischemic preconditioning (IPC) is a novel cell protection mechanism whereby brief periods of sublethal ischemia can protect the myocyte from prolonged ischemia-induced-injury. Recently, several papers suggested that phosphatidylinositol-3 kinase (PI3K) plays an important role in IPC protection. Our study examined the isoform specificity of PI3K in IPC using PI3Kgamma knockout (PI3Kgamma-/-) and PI3Kalpha dominant-negative (PI3KalphaDN) mice. Recovery rate in IPC group was significantly higher than I/R group in wild type hearts. However, the protective effect of IPC was completely abolished in PI3Kgamma-/- hearts. Surprisingly, PI3KalphaDN hearts showed significant recovery after both I/R and IPC. Therefore our studies suggested that PI3Kgamma isomer is involved in IPC and genetic inhibition of PI3Kalpha is resistant against ischemia. Furthermore, examining downstream of PI3K revealed that PI3Kgamma-PKB/Akt-GSK3beta signaling cascade is critical for regulating cell survival. Selective inhibition PI3Kalpha or activation of PI3Kalpha may be novel therapeutic strategies for protecting the ischemic myocardium.

Publish Date
Language
English
Pages
113

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Book Details


Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0732.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
113 leaves.
Number of pages
113

ID Numbers

Open Library
OL19217760M
ISBN 10
0494074884

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December 15, 2009 Edited by WorkBot link works
October 21, 2008 Created by ImportBot Imported from University of Toronto MARC record.