Audrey Niffenegger (born June 13, 1963 in South Haven, Michigan) is a writer and artist. She is also a professor in the Interdisciplinary Book Arts MFA Program at the Columbia College Chicago Center for Book and Paper Arts.

Niffenegger's debut novel, The Time Traveler's Wife (2003), was a national bestseller. The Time Traveler's Wife is an unconventional love story that centers on a man with a strange genetic disorder that causes him to unpredictably time-travel and his wife, an artist, who has to cope with his constant absence. The film version is due for release in 2008.